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High-Potency Cannabis Linked to Brain Damage, Experts Warn

High-Potency Cannabis Linked to Brain Damage, Experts Warn

by Liam Davenport
Medscape Psychiatry & Mental Health, December 15, 2015

WTR-RI Research & Analysis Team Comment:

This study, Effect of high-potency cannabis on corpus callosum microstructure was conducted by Silvia Rigucci, MD, Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Italy in collaboration with colleagues at the Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

Results indicate that regular use of today’s high potency strains of marijuana “is associated with disturbed callosal microstructure organization in individuals with and without psychosis”. (see abstract at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10044996&fulltextType=RA&fileId=S0033291715002342)

As the Medscape summary article notes, “Smoking high-potency, or “skunk”-like, cannabis may cause white matter damage in the corpus callosum, thus interfering with communication between the right and left hemispheres of the brain …” (see summary at article at http://www.medscape.com/viewarticle/855971?nlid=93987_2051&src=wnl_edit_medn_psyc&uac=238333HT&spon=12&impID=924712&faf=1#vp_1).


Psychotic illness appears to begin at younger age among those who use cannabis

Psychotic illness begins at younger age among those who use cannabis

Source:  (As reported in ScienceDaily, February 8, 2011)  JAMA and Archives Journals. (2011, February 8). Psychotic illness appears to begin at younger age among those who use cannabis. ScienceDaily.

Retrieved June 1, 2014 from www.sciencedaily.com/releases/2011/02/110207165434.htm

ScienceDaily Summary:

Cannabis use appears to be associated with an earlier onset of psychotic illness, according to a meta-analysis of previously published studies.

Journal Reference:

Matthew Large; Swapnil Sharma; Michael T. Compton; Tim Slade; Olav Nielssen. Cannabis Use and Earlier Onset of Psychosis: A Systematic Meta-analysisArch Gen Psychiatry, 2011; DOI: 10.1001/archgenpsychiatry.2011.5

WTR-RI Research & Analysis Team Note:

In their large study, the researchers “found that individuals who used cannabis developed psychosis about 2.7 years younger than those who did not use cannabis.”


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