Advocating for Evidence Based Marijuana Policy
Tag Archives: Genetics
Cannabis use mimics cognitive weakness that can lead to schizophrenia, fMRI study finds
Source: (As reported in ScienceDaily, November 2, 2012) Frontiers. (2012, November 2). Cannabis use mimics cognitive weakness that can lead to schizophrenia, fMRI study finds. ScienceDaily.
Retrieved June 9, 2014 from www.sciencedaily.com/releases/2012/11/121102084632.htm
Researchers in Norway have found new support for their theory that cannabis use causes a temporary cognitive breakdown in non-psychotic individuals, leading to long-term psychosis. In an fMRI study, researchers found a different brain activity pattern in schizophrenia patients with previous cannabis use than in schizophrenic patients without prior cannabis use.
Else-Marie Løberg, Merethe Nygård, Jan Øystein Berle, Erik Johnsen, Rune A. Kroken, Hugo A. Jørgensen, Kenneth Hugdahl. An fMRI Study of Neuronal Activation in Schizophrenia Patients with and without Previous Cannabis Use. Frontiers in Psychiatry, 2012; 3 DOI:10.3389/fpsyt.2012.00094
Gene implicated in schizophrenia risk is also associated with risk for cannabis dependence
Source: (As reported in ScienceDaily, October 11, 2012)
Elsevier. (2012, October 11). Gene implicated in schizophrenia risk is also associated with risk for cannabis dependence. ScienceDaily. Retrieved June 8, 2014 from www.sciencedaily.com/releases/2012/10/121011085342.htm
New research implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.
WTR-RI Research & Analysis Team Note:
Of particular relevance to mental health, according to this ScienceDaily article, is the possible connection of this study’s results and the fact that “… (these) findings may help to explain the already established link between cannabis use and the risk for developing schizophrenia. A number of epidemiologic studies have attributed the association of cannabis use and schizophrenia to the effects of cannabis on the brain rather than a common genetic link between these two conditions.”
Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, David Oslin, Raymond Anton, Lindsay A. Farrer, Joel Gelernter. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans. Biological Psychiatry, 2012; 72 (8): 637 DOI:10.1016/j.biopsych.2012.02.038
A risk gene for cannabis psychosis
Source: (As reported in ScienceDaily, November 14, 2012) Elsevier. (2012, November 14). A risk gene for cannabis psychosis. ScienceDaily.
Retrieved June 9, 2014 from www.sciencedaily.com/releases/2012/11/121114083928.htm
The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.
Marta Di Forti, Conrad Iyegbe, Hannah Sallis, Anna Kolliakou, M. Aurora Falcone, Alessandra Paparelli, Miriam Sirianni, Caterina La Cascia, Simona A. Stilo, Tiago Reis Marques, Rowena Handley, Valeria Mondelli, Paola Dazzan, Carmine Pariante, Anthony S. David, Craig Morgan, John Powell, Robin M. Murray. Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users. Biological Psychiatry, 2012; 72 (10): 811 DOI:10.1016/j.biopsych.2012.06.020