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Tag Archives: Potency

High-Potency Cannabis Linked to Brain Damage, Experts Warn

High-Potency Cannabis Linked to Brain Damage, Experts Warn

by Liam Davenport
Medscape Psychiatry & Mental Health, December 15, 2015

WTR-RI Research & Analysis Team Comment:

This study, Effect of high-potency cannabis on corpus callosum microstructure was conducted by Silvia Rigucci, MD, Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Italy in collaboration with colleagues at the Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

Results indicate that regular use of today’s high potency strains of marijuana “is associated with disturbed callosal microstructure organization in individuals with and without psychosis”. (see abstract at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10044996&fulltextType=RA&fileId=S0033291715002342)

As the Medscape summary article notes, “Smoking high-potency, or “skunk”-like, cannabis may cause white matter damage in the corpus callosum, thus interfering with communication between the right and left hemispheres of the brain …” (see summary at article at http://www.medscape.com/viewarticle/855971?nlid=93987_2051&src=wnl_edit_medn_psyc&uac=238333HT&spon=12&impID=924712&faf=1#vp_1).


An Overview of Known Qualities, Effects and Laws of Cannabidiol (CBD)

An Overview of Known Qualities, Effects and Laws of Cannabidiol (CBD)

California HIDTA Drug Demand Reduction Short Report Series:  Volume 1, Issue 1, April 2015

WTR-RI Research & Analysis Team Note:
This brief PDF provides up to date information on the state of the current research into and production of High CBD/Low THC products and extracts for potential medical marijuana use.  In particular, it addresses quality control and product safety concerns related to CBD Hemp Oil use in the often publicized case of a fast cycling childhood epilepsy condition known as Dravet Syndrome.

CBD Rich Hemp HIDTA Report Vo1 1 Issue 1

Legalizing marijuana and the new science of weed

Legalizing marijuana and the new science of weed

American Chemical Society (ACS). (2015, March 23). Legalizing marijuana and the new science of weed. ScienceDaily. Retrieved March 25, 2015 from http://www.sciencedaily.com/releases/2015/03/150323075237.htm
Science Daily Summary:
More than a year into Colorado’s experiment legalizing marijuana, labs testing the plants are able for the first time to take stock of the drug’s potency and contaminants – and openly paint a picture of what’s in today’s weed. Now, one such lab will present trends — and some surprises — that its preliminary testing has revealed about the marijuana now on the market. Scientists are studying potency, amounts of a substance called CBD and contaminants in the products.

Impact of Butane Hash Oil Fire at Kinsley Ave Mill on Legalization in RI?

Does the Kinsley Ave Fire Help or Hurt Marijuana Legalization in RI?

Tuesday, March 24, 2015


Marijuana use may double the risk of accidents for drivers, study finds

Marijuana use may double the risk of accidents for drivers, study finds

Source:  (As reported in ScienceDaily, October 7, 2011)  Columbia University’s Mailman School of Public Health. (2011, October 7). Marijuana use may double the risk of accidents for drivers, study finds. ScienceDaily. Retrieved May 20, 2014 from www.sciencedaily.com/releases/2011/10/111006173453.htm

ScienceDaily Summary:

Researchers have found that drivers who test positive for marijuana or report driving within three hours of marijuana use are more than twice as likely as other drivers to be involved in motor vehicle crashes. The researchers also found evidence that crash risk increases with the concentration of marijuana-produced compounds in the urine and the frequency of self-reported marijuana use.

Journal Reference:

M.-C. Li, J. E. Brady, C. J. DiMaggio, A. R. Lusardi, K. Y. Tzong, G. Li. Marijuana Use and Motor Vehicle Crashes. Epidemiologic Reviews, 2011; DOI: 10.1093/epirev/mxr017

Reclassification of cannabis in England linked to increased psychosis.

Reclassification of cannabis linked to cannabis psychosis

Source:  (As reported in ScienceDaily, July 18, 2013)  University of York. (2013, July 18). Reclassification of cannabis linked to cannabis psychosis. ScienceDaily. Retrieved June 1, 2014 from http://www.sciencedaily.com/releases/2013/07/130718101156.htm

ScienceDaily Summary:

Researchers have demonstrated that the change in cannabis declassification in 2009 has coincided with a significant increase in hospital admissions for cannabis psychosis – rather than the decrease it was intended to produce.

Journal Reference:

Ian Hamilton, Charlie Lloyd, Catherine Hewitt, Christine Godfrey. Effect of reclassification of cannabis on hospital admissions for cannabis psychosis: A time series analysisInternational Journal of Drug Policy, 2013; DOI: 10.1016/j.drugpo.2013.05.016

WTR-RI Research & Analysis Team Note:

(The following is an excerpt from abstract of the above noted Journal Reference.  It is included here to clarify the references to the British controlled drug categories referenced in the preceding two ScienceDaily summaries.  The link to the abstract is http://www.ijdp.org/article/S0955-3959(13)00090-X/abstract)

“The UK Misuse of Drugs Act (1971) divided controlled drugs into three groups A, B and C, with descending criminal sanctions attached to each class. Cannabis was originally assigned by the Act to Group B but in 2004, it was transferred to the lowest risk group, Group C. Then in 2009, on the basis of increasing concerns about a link between high strength cannabis and schizophrenia, it was moved back to Group B. The aim of this study is to test the assumption that changes in classification lead to changes in levels of psychosis. In particular, it explores whether the two changes in 2004 and 2009 were associated with changes in the numbers of people admitted for cannabis psychosis.”

Some truth to the ‘potent pot myth’

Some truth to the ‘potent pot myth’

Source:  (As reported in ScienceDaily, March 18, 2014)  Wiley. (2014, March 18). Some truth to the ‘potent pot myth’. ScienceDaily. Retrieved June 9, 2014 from www.sciencedaily.com/releases/2014/03/140318093906.htm

ScienceDaily Summary:

People who smoke high-potency cannabis end up getting higher doses of the active ingredient, new research from the Netherlands shows. Although they reduce the amount they puff and inhale to compensate for the higher strength, they still take in more of the active ingredient than smokers of lower potency cannabis.

Journal Reference:

Peggy van der Pol, Nienke Liebregts, Tibor Brunt, Jan van Amsterdam, Ron de Graaf, Dirk J. Korf, Wim van den Brink, Margriet van Laar. Cross-sectional and prospective relation of cannabis potency, dosing and smoking behaviour with cannabis dependence: an ecological study.Addiction, 2014; DOI: 10.1111/add.12508

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