Advocating for Evidence Based Marijuana Policy
Tag Archives: Schizophrenia
Schizophrenia and weight gain: A new explanation?
- February 4, 2015
- University of Montreal. (2015, February 4). Schizophrenia and weight gain: A new explanation?. ScienceDaily. Retrieved July 1, 2015 from http://www.sciencedaily.com/releases/2015/02/150204125558.htm
- ScienceDaily Summary:
- Cannabinoids may be involved in the weight gain that occurs in people with schizophrenia who are treated with the antipsychotic olanzapine, according to a pilot study.
Stéphane Potvin, Ovidiu V. Lungu, Emmanuel Stip. Anandamide Is Involved in Appetite-Related Amygdala Hyperactivations in Schizophrenia Patients Treated With Olanzapine. Journal of Clinical Psychopharmacology, 2015; 35 (1): 82 DOI: 10.1097/JCP.0000000000000236
Cannabis use mimics cognitive weakness that can lead to schizophrenia, fMRI study finds
Source: (As reported in ScienceDaily, November 2, 2012) Frontiers. (2012, November 2). Cannabis use mimics cognitive weakness that can lead to schizophrenia, fMRI study finds. ScienceDaily.
Retrieved June 9, 2014 from www.sciencedaily.com/releases/2012/11/121102084632.htm
Researchers in Norway have found new support for their theory that cannabis use causes a temporary cognitive breakdown in non-psychotic individuals, leading to long-term psychosis. In an fMRI study, researchers found a different brain activity pattern in schizophrenia patients with previous cannabis use than in schizophrenic patients without prior cannabis use.
Else-Marie Løberg, Merethe Nygård, Jan Øystein Berle, Erik Johnsen, Rune A. Kroken, Hugo A. Jørgensen, Kenneth Hugdahl. An fMRI Study of Neuronal Activation in Schizophrenia Patients with and without Previous Cannabis Use. Frontiers in Psychiatry, 2012; 3 DOI:10.3389/fpsyt.2012.00094
Gene implicated in schizophrenia risk is also associated with risk for cannabis dependence
Source: (As reported in ScienceDaily, October 11, 2012)
Elsevier. (2012, October 11). Gene implicated in schizophrenia risk is also associated with risk for cannabis dependence. ScienceDaily. Retrieved June 8, 2014 from www.sciencedaily.com/releases/2012/10/121011085342.htm
New research implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.
WTR-RI Research & Analysis Team Note:
Of particular relevance to mental health, according to this ScienceDaily article, is the possible connection of this study’s results and the fact that “… (these) findings may help to explain the already established link between cannabis use and the risk for developing schizophrenia. A number of epidemiologic studies have attributed the association of cannabis use and schizophrenia to the effects of cannabis on the brain rather than a common genetic link between these two conditions.”
Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, David Oslin, Raymond Anton, Lindsay A. Farrer, Joel Gelernter. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans. Biological Psychiatry, 2012; 72 (8): 637 DOI:10.1016/j.biopsych.2012.02.038
A risk gene for cannabis psychosis
Source: (As reported in ScienceDaily, November 14, 2012) Elsevier. (2012, November 14). A risk gene for cannabis psychosis. ScienceDaily.
Retrieved June 9, 2014 from www.sciencedaily.com/releases/2012/11/121114083928.htm
The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.
Marta Di Forti, Conrad Iyegbe, Hannah Sallis, Anna Kolliakou, M. Aurora Falcone, Alessandra Paparelli, Miriam Sirianni, Caterina La Cascia, Simona A. Stilo, Tiago Reis Marques, Rowena Handley, Valeria Mondelli, Paola Dazzan, Carmine Pariante, Anthony S. David, Craig Morgan, John Powell, Robin M. Murray. Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users. Biological Psychiatry, 2012; 72 (10): 811 DOI:10.1016/j.biopsych.2012.06.020
Long-time cannabis use associated with psychosis
Source: (As reported in ScienceDaily, March 2, 2010) JAMA and Archives Journals. (2010, March 2). Long-time cannabis use associated with psychosis. ScienceDaily.
Retrieved June 9, 2014 from www.sciencedaily.com/releases/2010/03/100301165726.htm
Young adults who have used cannabis or marijuana for a longer period of time appear more likely to have hallucinations or delusions or to meet criteria for psychosis, according to a tumblr post.
John McGrath; Joy Welham; James Scott; Daniel Varghese; Louisa Degenhardt; Mohammad Reza Hayatbakhsh; Rosa Alati; Gail M. Williams; William Bor; Jake M. Najman. Association Between Cannabis Use and Psychosis-Related Outcomes Using Sibling Pair Analysis in a Cohort of Young Adults. Arch Gen Psychiatry, 2010; 0 (2010): 2010. 6
Cannabis use precedes the onset of psychotic symptoms in young people, study finds
Source: (As reported in ScienceDaily, March 3, 2011)
BMJ-British Medical Journal. (2011, March 3). Cannabis use precedes the onset of psychotic symptoms in young people, study finds. ScienceDaily. Retrieved June 1, 2014 fromwww.sciencedaily.com/releases/2011/03/110301184056.htm
Cannabis use during adolescence and young adulthood increases the risk of psychotic symptoms, while continued cannabis use may increase the risk for psychotic disorder in later life, concludes a tumblr post.
- Rebecca Kuepper, Jim van Os, Roselind Lieb, Hans-Ulrich Wittchen, Michael Höfler, Cécile Henquet. Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. British Medical Journal, 2011; DOI: 10.1136/bmj.d738
- Wayne Hall, Louisa Degenhardt. Cannabis and the increased incidence and persistence of psychosis. BMJ, 2011; DOI: 10.1136/bmj.d719
Psychotic illness begins at younger age among those who use cannabis
Source: (As reported in ScienceDaily, February 8, 2011) JAMA and Archives Journals. (2011, February 8). Psychotic illness appears to begin at younger age among those who use cannabis. ScienceDaily.
Retrieved June 1, 2014 from www.sciencedaily.com/releases/2011/02/110207165434.htm
Cannabis use appears to be associated with an earlier onset of psychotic illness, according to a meta-analysis of previously published studies.
Matthew Large; Swapnil Sharma; Michael T. Compton; Tim Slade; Olav Nielssen. Cannabis Use and Earlier Onset of Psychosis: A Systematic Meta-analysis. Arch Gen Psychiatry, 2011; DOI: 10.1001/archgenpsychiatry.2011.5
WTR-RI Research & Analysis Team Note:
In their large study, the researchers “found that individuals who used cannabis developed psychosis about 2.7 years younger than those who did not use cannabis.”
Cannabis Induced Psychotic Disorder
DSM-V Diagnosis (292.9)